Prediction of the functional refractory period of the atrioventricular node

Peter E. Dresel; Ricky Y.K. Man

doi:10.1016/S0022-0736(78)80101-0

Prediction of the functional refractory period of the atrioventricular node

Peter E. Dresel, Ricky Y.K. Man

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

2 Citations (Scopus)

Résumé

Based on the new description of AV-nodal conductivity from our laboratory, we developed an equation which describes AV-nodal conduction time in the dog heart at all coupling intervals. This allows us to predict the functional refractory period (FRP) of the AV-node based on the AV-nodal conduction times of only five extra stimuli having relatively long coupling intervals. The equation predicted the FRP within acceptable limits when compared to values obtained by the classical technique in which the full range of extrasystolic intervals must be tested. Changes in FRP after the administration of antirrrhythmic drugs (lidocaine and quinidine) or due to changes in heart rate were predicted accurately. The ease and accuracy of the present method could allow determination of FRP in a short time.

Langue d'origine	English
Pages (de-à)	123-127
Nombre de pages	5
Journal	Journal of Electrocardiology
Volume	11
Numéro de publication	2
DOI	https://doi.org/10.1016/S0022-0736(78)80101-0
Statut de publication	Published - 1978

Note bibliographique

Funding Information:
The concept of the functional refractory period of atrioventricular transmission was developed by Krayer et al, 1 who studied the effect of epinephrine and veratramine on the transmission of impulses between atria and ventricles. It has been commonly employed to determine the effect of physiological, pharmacological and pathological factors on atrioventricular conduction. It is defined as the minimum interval between ventricular activations which are conducted from the versity, Halifax, Nova Scotia, Canada, and the Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Aided by grants from the Medical Research Council of Canada and the Manitoba Heart Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. w1 734 solely to indicate this fact. *Graduate Fellow, Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, P.Q., Canada. Reprint requests to: Peter E. Dresel, Ph.D., Professor and Head, Department of Pharmacology, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 4H7.

ASJC Scopus Subject Areas

Cardiology and Cardiovascular Medicine

PubMed: MeSH publication types

Journal Article

Accès au document

10.1016/S0022-0736(78)80101-0

Autres fichiers et liens

Citer

@article{d99c31daaea449a298ebc125508e12d1,

title = "Prediction of the functional refractory period of the atrioventricular node",

abstract = "Based on the new description of AV-nodal conductivity from our laboratory, we developed an equation which describes AV-nodal conduction time in the dog heart at all coupling intervals. This allows us to predict the functional refractory period (FRP) of the AV-node based on the AV-nodal conduction times of only five extra stimuli having relatively long coupling intervals. The equation predicted the FRP within acceptable limits when compared to values obtained by the classical technique in which the full range of extrasystolic intervals must be tested. Changes in FRP after the administration of antirrrhythmic drugs (lidocaine and quinidine) or due to changes in heart rate were predicted accurately. The ease and accuracy of the present method could allow determination of FRP in a short time.",

author = "Dresel, {Peter E.} and Man, {Ricky Y.K.}",

note = "Funding Information: The concept of the functional refractory period of atrioventricular transmission was developed by Krayer et al, 1 who studied the effect of epinephrine and veratramine on the transmission of impulses between atria and ventricles. It has been commonly employed to determine the effect of physiological, pharmacological and pathological factors on atrioventricular conduction. It is defined as the minimum interval between ventricular activations which are conducted from the versity, Halifax, Nova Scotia, Canada, and the Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Aided by grants from the Medical Research Council of Canada and the Manitoba Heart Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked {"}advertisement{"} in accordance with 18 U.S.C. w1 734 solely to indicate this fact. *Graduate Fellow, Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, P.Q., Canada. Reprint requests to: Peter E. Dresel, Ph.D., Professor and Head, Department of Pharmacology, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 4H7.",

year = "1978",

doi = "10.1016/S0022-0736(78)80101-0",

language = "English",

volume = "11",

pages = "123--127",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Churchill Livingstone",

number = "2",

}

TY - JOUR

T1 - Prediction of the functional refractory period of the atrioventricular node

AU - Dresel, Peter E.

AU - Man, Ricky Y.K.

N1 - Funding Information: The concept of the functional refractory period of atrioventricular transmission was developed by Krayer et al, 1 who studied the effect of epinephrine and veratramine on the transmission of impulses between atria and ventricles. It has been commonly employed to determine the effect of physiological, pharmacological and pathological factors on atrioventricular conduction. It is defined as the minimum interval between ventricular activations which are conducted from the versity, Halifax, Nova Scotia, Canada, and the Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Aided by grants from the Medical Research Council of Canada and the Manitoba Heart Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. w1 734 solely to indicate this fact. *Graduate Fellow, Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, P.Q., Canada. Reprint requests to: Peter E. Dresel, Ph.D., Professor and Head, Department of Pharmacology, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 4H7.

PY - 1978

Y1 - 1978

N2 - Based on the new description of AV-nodal conductivity from our laboratory, we developed an equation which describes AV-nodal conduction time in the dog heart at all coupling intervals. This allows us to predict the functional refractory period (FRP) of the AV-node based on the AV-nodal conduction times of only five extra stimuli having relatively long coupling intervals. The equation predicted the FRP within acceptable limits when compared to values obtained by the classical technique in which the full range of extrasystolic intervals must be tested. Changes in FRP after the administration of antirrrhythmic drugs (lidocaine and quinidine) or due to changes in heart rate were predicted accurately. The ease and accuracy of the present method could allow determination of FRP in a short time.

AB - Based on the new description of AV-nodal conductivity from our laboratory, we developed an equation which describes AV-nodal conduction time in the dog heart at all coupling intervals. This allows us to predict the functional refractory period (FRP) of the AV-node based on the AV-nodal conduction times of only five extra stimuli having relatively long coupling intervals. The equation predicted the FRP within acceptable limits when compared to values obtained by the classical technique in which the full range of extrasystolic intervals must be tested. Changes in FRP after the administration of antirrrhythmic drugs (lidocaine and quinidine) or due to changes in heart rate were predicted accurately. The ease and accuracy of the present method could allow determination of FRP in a short time.

UR - http://www.scopus.com/inward/record.url?scp=0017864606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017864606&partnerID=8YFLogxK

U2 - 10.1016/S0022-0736(78)80101-0

DO - 10.1016/S0022-0736(78)80101-0

M3 - Article

C2 - 660015

AN - SCOPUS:0017864606

SN - 0022-0736

VL - 11

SP - 123

EP - 127

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 2

ER -

Prediction of the functional refractory period of the atrioventricular node

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer