Reaginic antibody formation in mice injected with rabbit anti mouse thymocyte serum

L. S. Kind; B. Macedo Sobrinho

doi:10.1159/000231077

Reaginic antibody formation in mice injected with rabbit anti mouse thymocyte serum

L. S. Kind, B. Macedo Sobrinho

Medicine

Medicine

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13 Citas (Scopus)

Resumen

A new model system for inducing reaginic antibody formation in mice is presented, namely a single injection of rabbit anti mouse thymocyte serum (RAMTS). Using this model it is shown that X irradiation (450 rad) administered to CBA mice 24 hr after a single injection of RAMTS or IgG (RAMTS) results in a sustained moderately high level of reagins against rabbit serum proteins with a concomitant barely detectable level (titer 1:5) of γ₁ antibodies. Splenectomy and thymectomy had no demonstrable effect on reaginic antibody synthesis.

Idioma original	English
Páginas (desde-hasta)	780-788
Número de páginas	9
Publicación	International Archives of Allergy and Applied Immunology
Volumen	45
N.º	5
DOI	https://doi.org/10.1159/000231077
Estado	Published - 1973

ASJC Scopus Subject Areas

Immunology and Allergy

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abstract = "A new model system for inducing reaginic antibody formation in mice is presented, namely a single injection of rabbit anti mouse thymocyte serum (RAMTS). Using this model it is shown that X irradiation (450 rad) administered to CBA mice 24 hr after a single injection of RAMTS or IgG (RAMTS) results in a sustained moderately high level of reagins against rabbit serum proteins with a concomitant barely detectable level (titer 1:5) of γ1 antibodies. Splenectomy and thymectomy had no demonstrable effect on reaginic antibody synthesis.",

author = "Kind, {L. S.} and {Macedo Sobrinho}, B.",

year = "1973",

doi = "10.1159/000231077",

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AU - Kind, L. S.

AU - Macedo Sobrinho, B.

PY - 1973

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AB - A new model system for inducing reaginic antibody formation in mice is presented, namely a single injection of rabbit anti mouse thymocyte serum (RAMTS). Using this model it is shown that X irradiation (450 rad) administered to CBA mice 24 hr after a single injection of RAMTS or IgG (RAMTS) results in a sustained moderately high level of reagins against rabbit serum proteins with a concomitant barely detectable level (titer 1:5) of γ1 antibodies. Splenectomy and thymectomy had no demonstrable effect on reaginic antibody synthesis.

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JF - International Archives of Allergy and Applied Immunology

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ER -

Reaginic antibody formation in mice injected with rabbit anti mouse thymocyte serum

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