Relative shift in activity from medial to lateral frontal cortex during internally versus externally guided word generation

Bruce Crosson, Joseph R. Sadek, Leeza Maron, Didem Gökçay, Cecile M. Mohr, Edward J. Auerbach, Alan J. Freeman, Christiana M. Leonard, Richard W. Briggs

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

135 Citas (Scopus)

Resumen

Goldberg (1985) hypothesized that as language output changes from internally to externally guided production, activity shifts from supplementary motor area (SMA) to lateral premotor areas, including Broca's area. To nest this hypothesis, 15 right-handed native English speakers performed three word generation tasks varying in the amount of internal guidance and a repetition task during functional magnetic resonance imaging (fMRI). Volumes of significant activity for each task versus a resting state were derived using voxel-by-voxel repeated-measures t tests (p < .001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided.

Idioma originalEnglish
Páginas (desde-hasta)272-283
Número de páginas12
PublicaciónJournal of Cognitive Neuroscience
Volumen13
N.º2
DOI
EstadoPublished - feb. 15 2001
Publicado de forma externa

ASJC Scopus Subject Areas

  • Cognitive Neuroscience

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