Relative shift in activity from medial to lateral frontal cortex during internally versus externally guided word generation

Bruce Crosson, Joseph R. Sadek, Leeza Maron, Didem Gökçay, Cecile M. Mohr, Edward J. Auerbach, Alan J. Freeman, Christiana M. Leonard, Richard W. Briggs

Résultat de recherche: Articleexamen par les pairs

135 Citations (Scopus)

Résumé

Goldberg (1985) hypothesized that as language output changes from internally to externally guided production, activity shifts from supplementary motor area (SMA) to lateral premotor areas, including Broca's area. To nest this hypothesis, 15 right-handed native English speakers performed three word generation tasks varying in the amount of internal guidance and a repetition task during functional magnetic resonance imaging (fMRI). Volumes of significant activity for each task versus a resting state were derived using voxel-by-voxel repeated-measures t tests (p < .001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided.

Langue d'origineEnglish
Pages (de-à)272-283
Nombre de pages12
JournalJournal of Cognitive Neuroscience
Volume13
Numéro de publication2
DOI
Statut de publicationPublished - févr. 15 2001
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Cognitive Neuroscience

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