T lymphocytes mediate leaflet destruction and allograft aortic valve failure in rats

Jean François Legare, Tim D.G. Lee, Kimberley Creaser, David B. Ross, Marjorie Green

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

41 Citas (Scopus)

Resumen

Background: Allograft heart valves are commonly used in cardiac surgery but ultimately fail. This situation is most acute in children. This study addresses the role of T cell-mediated immune damage in allograft valve failure. Methods: Syngeneic (Lewis to Lewis) or allogeneic (Brown Norway to Lewis) aortic valve grafts were implanted infrarenally into Lewis rat recipients (n = 24). Allogeneic valve grafts were also implanted into T cell-deficient rats (nude; n = 12). At 7, 14, and 28 days the valves were explanted and examined for structural integrity and cellular infiltration. Results: Syngeneic grafts maintained normal leaflet structure with little leaflet immune infiltration. Allografts showed leaflet infiltration (7 days), significant leaflet thickening, progressively decreased cellularity (14 days), and leaflet destruction (28 days). Infiltrates contained CD43+, CD3+, and CDS+ cells. Allografts in T cell-deficient rats showed none of the above changes and maintained normal structural integrity. Conclusions: Allograft heart valves in the rat model undergo T cell-mediated immune rejection, resulting in structural failure. (C) 2000 by The Society of Thoracic Surgeons.

Idioma originalEnglish
Páginas (desde-hasta)1238-1245
Número de páginas8
PublicaciónAnnals of Thoracic Surgery
Volumen70
N.º4
DOI
EstadoPublished - 2000

Nota bibliográfica

Funding Information:
This work was supported by The Toronto Hospital for Sick Children Research Foundation.

ASJC Scopus Subject Areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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