Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma

Barry E. Kennedy; Maryanne Sadek; Manal O. Elnenaei; Anthony Reiman; Shashi A. Gujar

doi:10.1016/j.trecan.2019.11.005

Targeting NAD⁺ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma

Barry E. Kennedy, Maryanne Sadek, Manal O. Elnenaei, Anthony Reiman, Shashi A. Gujar

Medicine

Producción científica: Contribución a una revista › Encuesta corta › revisión exhaustiva

16 Citas (Scopus)

Resumen

Antibodies targeting CD38, a NAD⁺-degrading enzyme, have emerged as a promising immunotherapy against multiple myeloma (MM). Currently, the mechanisms by which anti-CD38 antibodies establish their therapeutic effects are poorly understood. Here, we advocate for the depletion of NAD⁺ to enhance the efficacy of anti-CD38-based immunotherapies in MM.

Idioma original	English
Páginas (desde-hasta)	9-12
Número de páginas	4
Publicación	Trends in Cancer
Volumen	6
N.º	1
DOI	https://doi.org/10.1016/j.trecan.2019.11.005
Estado	Published - ene. 2020

Nota bibliográfica

Funding Information:
This work was supported by grants from the Canadian Cancer Society (CRS), the Canadian Cancer Society Research Institute (CCSRI), the Canadian Institutes of Health Research (CIHR), and the Beatrice Hunter Cancer Research Institute (BHCRI) to S.A.G. B.E.K. is a trainee in the Cancer Research Training Program (CRTP) of the BHCRI with funding from the Terry Fox Research Institute (TFRI). S.A.G. is supported by Dalhousie Medical Research Foundation (DMRF).

Publisher Copyright:
© 2019

ASJC Scopus Subject Areas

Oncology
Cancer Research

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