Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma

Barry E. Kennedy; Maryanne Sadek; Manal O. Elnenaei; Anthony Reiman; Shashi A. Gujar

doi:10.1016/j.trecan.2019.11.005

Targeting NAD⁺ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma

Barry E. Kennedy, Maryanne Sadek, Manal O. Elnenaei, Anthony Reiman, Shashi A. Gujar

Medicine

Résultat de recherche: Short survey › examen par les pairs

16 Citations (Scopus)

Résumé

Antibodies targeting CD38, a NAD⁺-degrading enzyme, have emerged as a promising immunotherapy against multiple myeloma (MM). Currently, the mechanisms by which anti-CD38 antibodies establish their therapeutic effects are poorly understood. Here, we advocate for the depletion of NAD⁺ to enhance the efficacy of anti-CD38-based immunotherapies in MM.

Langue d'origine	English
Pages (de-à)	9-12
Nombre de pages	4
Journal	Trends in Cancer
Volume	6
Numéro de publication	1
DOI	https://doi.org/10.1016/j.trecan.2019.11.005
Statut de publication	Published - janv. 2020

Note bibliographique

Funding Information:
This work was supported by grants from the Canadian Cancer Society (CRS), the Canadian Cancer Society Research Institute (CCSRI), the Canadian Institutes of Health Research (CIHR), and the Beatrice Hunter Cancer Research Institute (BHCRI) to S.A.G. B.E.K. is a trainee in the Cancer Research Training Program (CRTP) of the BHCRI with funding from the Terry Fox Research Institute (TFRI). S.A.G. is supported by Dalhousie Medical Research Foundation (DMRF).

Publisher Copyright:
© 2019

ASJC Scopus Subject Areas

Oncology
Cancer Research

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1016/j.trecan.2019.11.005

Autres fichiers et liens

Citer

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abstract = "Antibodies targeting CD38, a NAD+-degrading enzyme, have emerged as a promising immunotherapy against multiple myeloma (MM). Currently, the mechanisms by which anti-CD38 antibodies establish their therapeutic effects are poorly understood. Here, we advocate for the depletion of NAD+ to enhance the efficacy of anti-CD38-based immunotherapies in MM.",

author = "Kennedy, {Barry E.} and Maryanne Sadek and Elnenaei, {Manal O.} and Anthony Reiman and Gujar, {Shashi A.}",

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AU - Gujar, Shashi A.

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