The role of prenatal, obstetric and neonatal factors in the development of autism

Linda Dodds; Deshayne B. Fell; Sarah Shea; B. Anthony Armson; Alexander C. Allen; Susan Bryson

doi:10.1007/s10803-010-1114-8

The role of prenatal, obstetric and neonatal factors in the development of autism

Linda Dodds, Deshayne B. Fell, Sarah Shea, B. Anthony Armson, Alexander C. Allen, Susan Bryson

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

221 Citas (Scopus)

Resumen

We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.

Idioma original	English
Páginas (desde-hasta)	891-902
Número de páginas	12
Publicación	Journal of Autism and Developmental Disorders
Volumen	41
N.º	7
DOI	https://doi.org/10.1007/s10803-010-1114-8
Estado	Published - jul. 2011

Nota bibliográfica

Funding Information:
Acknowledgment The authors thank the Reproductive Care Program of Nova Scotia and the Population Health Research Unit at Dalhousie University for facilitating access to the data and Anne Spencer for help with data analysis. This study was funded by a grant from the Cure Autism Now Foundation (now Autism Speaks). Although this research is based in part on data obtained from the Population Health Research Unit, the observations and opinions expressed are those of the authors and do not represent those of the Population Health Research Unit.

ASJC Scopus Subject Areas

Developmental and Educational Psychology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1007/s10803-010-1114-8

Otros archivos y enlaces

Citar esto

@article{0e727e55146444618240b82317479beb,

title = "The role of prenatal, obstetric and neonatal factors in the development of autism",

abstract = "We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.",

author = "Linda Dodds and Fell, {Deshayne B.} and Sarah Shea and Armson, {B. Anthony} and Allen, {Alexander C.} and Susan Bryson",

note = "Funding Information: Acknowledgment The authors thank the Reproductive Care Program of Nova Scotia and the Population Health Research Unit at Dalhousie University for facilitating access to the data and Anne Spencer for help with data analysis. This study was funded by a grant from the Cure Autism Now Foundation (now Autism Speaks). Although this research is based in part on data obtained from the Population Health Research Unit, the observations and opinions expressed are those of the authors and do not represent those of the Population Health Research Unit.",

year = "2011",

month = jul,

doi = "10.1007/s10803-010-1114-8",

language = "English",

volume = "41",

pages = "891--902",

journal = "Journal of Autism and Developmental Disorders",

issn = "0162-3257",

publisher = "Springer New York",

number = "7",

}

TY - JOUR

T1 - The role of prenatal, obstetric and neonatal factors in the development of autism

AU - Dodds, Linda

AU - Fell, Deshayne B.

AU - Shea, Sarah

AU - Armson, B. Anthony

AU - Allen, Alexander C.

AU - Bryson, Susan

N1 - Funding Information: Acknowledgment The authors thank the Reproductive Care Program of Nova Scotia and the Population Health Research Unit at Dalhousie University for facilitating access to the data and Anne Spencer for help with data analysis. This study was funded by a grant from the Cure Autism Now Foundation (now Autism Speaks). Although this research is based in part on data obtained from the Population Health Research Unit, the observations and opinions expressed are those of the authors and do not represent those of the Population Health Research Unit.

PY - 2011/7

Y1 - 2011/7

N2 - We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.

AB - We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.

UR - http://www.scopus.com/inward/record.url?scp=79959832142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959832142&partnerID=8YFLogxK

U2 - 10.1007/s10803-010-1114-8

DO - 10.1007/s10803-010-1114-8

M3 - Article

C2 - 20922473

AN - SCOPUS:79959832142

SN - 0162-3257

VL - 41

SP - 891

EP - 902

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 7

ER -

The role of prenatal, obstetric and neonatal factors in the development of autism

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto