Résumé
We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 891-902 |
| Nombre de pages | 12 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 41 |
| Numéro de publication | 7 |
| DOI | |
| Statut de publication | Published - juill. 2011 |
Note bibliographique
Funding Information:Acknowledgment The authors thank the Reproductive Care Program of Nova Scotia and the Population Health Research Unit at Dalhousie University for facilitating access to the data and Anne Spencer for help with data analysis. This study was funded by a grant from the Cure Autism Now Foundation (now Autism Speaks). Although this research is based in part on data obtained from the Population Health Research Unit, the observations and opinions expressed are those of the authors and do not represent those of the Population Health Research Unit.
ASJC Scopus Subject Areas
- Developmental and Educational Psychology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
ODD de l’ONU
Cette action contribue à la réalisation des objectifs de développement durable suivants
