The truth about genetic variation in the serotonin transporter gene and response to stress and medication

Peter McGuffin; Shaza Alsabban; Rudolf Uher

doi:10.1192/bjp.bp.110.085225

The truth about genetic variation in the serotonin transporter gene and response to stress and medication

Peter McGuffin, Shaza Alsabban, Rudolf Uher

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

40 Citas (Scopus)

Resumen

The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.

Idioma original	English
Páginas (desde-hasta)	424-427
Número de páginas	4
Publicación	British Journal of Psychiatry
Volumen	198
N.º	6
DOI	https://doi.org/10.1192/bjp.bp.110.085225
Estado	Published - jun. 2011
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

Psychiatry and Mental health

PubMed: MeSH publication types

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10.1192/bjp.bp.110.085225

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The truth about genetic variation in the serotonin transporter gene and response to stress and medication

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ASJC Scopus Subject Areas

PubMed: MeSH publication types

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