The truth about genetic variation in the serotonin transporter gene and response to stress and medication

Peter McGuffin, Shaza Alsabban, Rudolf Uher

Résultat de recherche: Review articleexamen par les pairs

40 Citations (Scopus)

Résumé

The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.

Langue d'origineEnglish
Pages (de-à)424-427
Nombre de pages4
JournalBritish Journal of Psychiatry
Volume198
Numéro de publication6
DOI
Statut de publicationPublished - juin 2011
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Psychiatry and Mental health

PubMed: MeSH publication types

  • Editorial
  • Comment

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