Résumé
A method is described for the extraction and purification of a permeability-enhancing factor (PEF) from ragweed pollen. PEF is a neutral polysaccharidic compound composed of arabinose and galactose associated with small amounts of pigment and protein. As little as 35 mcg. of PEF, when injected intravenously into mice along with Evans blue dye, will induce blueing in the ears of these animals. Blueing of the ears is likely due to the release of histamine, since the administration of PEF results in the disruption of the mast cells in the ears of mice. In addition, mice injected repeatedly with compound 48/80, a material which depletes tissues of their histamine, are no longer able to respond to PEF with ear blueing. It is suggested that PEF acts by combining with natural antibody present in mouse serum or on mouse mast cells.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 17-24 |
| Nombre de pages | 8 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 39 |
| Numéro de publication | 1 |
| DOI | |
| Statut de publication | Published - janv. 1967 |
| Publié à l'externe | Oui |
Note bibliographique
Funding Information:From the Department of Asthma-A’@gy National Jewish Hospital, Denver, Cola., Roosevelt Hospital, New York, N. Y. Supported by g-rants from the National and AI-02682. Presented at the Twenty-second New York, N. Y., Feb. 22, 1966. Received for publication May 9, 196ti.
ASJC Scopus Subject Areas
- General Medicine
PubMed: MeSH publication types
- Journal Article