Résumé
Objective: The histopathologic changes of fresh rat aortic valve allografts over time and the effect of cryopreservation were examined. Methods: Fifty-six syngeneic and allogeneic rat aortic valves were transplanted, either fresh or after cryopreservation, and then at different time points they were explanted and histologically examined in a blinded fashion. Results: Histopathologic changes in the first week are similar in syngeneic and allogeneic grafts. Fresh syngeneic grafts and leaflets retained normal structure up to 56 days. Allogeneic grafts showed retrovalvular thrombus formation with leaflet ghosts and neointimal proliferation. Cryopreservation did not alter this process. Conclusions: Cardiac allograft valves in the rat model undergo changes that are characteristic of cell- mediated rejection and lead to valve failure.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 891-902 |
| Nombre de pages | 12 |
| Journal | Journal of Thoracic and Cardiovascular Surgery |
| Volume | 114 |
| Numéro de publication | 6 |
| DOI | |
| Statut de publication | Published - 1997 |
| Publié à l'externe | Oui |
Note bibliographique
Funding Information:We gratefully acknowledge the financial support of the Izaak-Walton-Killam Hospital for Children to this study. We thank Mr. Lewis Page, Mr. André Le Prairie, and members of the Regional Tissue Bank, Queen Elizabeth II Health Sciences Centre, Halifax, Canada, for their assistance with the cryopreservation. In addition we would like to thank Mrs. Mary Wile for her expertise with the histologic preparation.
ASJC Scopus Subject Areas
- Surgery
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't