TY - GEN
T1 - Body surface potential mapping and computer simulation of human ventricular fibrillation
AU - Fitz-Clarke, John R.
AU - Sapp, J. L.
AU - Warren, J. W.
AU - Clements, J. C.
AU - Horáček, B. M.
PY - 2006
Y1 - 2006
N2 - Our aim was to study the electrical characteristics of human ventricular fibrillation (VF) by means of body surface potential mapping and heart-model simulations. We acquired 120-lead ECG data on the chest surface of patients undergoing controlled testing of implantable defibrillators. VF was induced by burst pacing, and ECGs were recorded for 5 to 7 seconds before the device delivered a rescue shock. We then used orthogonal decomposition to characterize spatial and temporal features of ECGs, and inverse solution to derive epicardial potential maps. To gain insight into mechanisms of VF, we used an anisotropic bidomain model of the human ventricular myocardium, featuring 5 ionic currents. The model showed meandering VF scroll waves exhibiting break-up and coalescence according to choice of ionic-current parameters. This combination of experiments and simulations offers a unique perspective on the origin of spatial patterns of ECG during VF.
AB - Our aim was to study the electrical characteristics of human ventricular fibrillation (VF) by means of body surface potential mapping and heart-model simulations. We acquired 120-lead ECG data on the chest surface of patients undergoing controlled testing of implantable defibrillators. VF was induced by burst pacing, and ECGs were recorded for 5 to 7 seconds before the device delivered a rescue shock. We then used orthogonal decomposition to characterize spatial and temporal features of ECGs, and inverse solution to derive epicardial potential maps. To gain insight into mechanisms of VF, we used an anisotropic bidomain model of the human ventricular myocardium, featuring 5 ionic currents. The model showed meandering VF scroll waves exhibiting break-up and coalescence according to choice of ionic-current parameters. This combination of experiments and simulations offers a unique perspective on the origin of spatial patterns of ECG during VF.
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M3 - Conference contribution
AN - SCOPUS:48049110402
SN - 1424425328
SN - 9781424425327
T3 - Computers in Cardiology
SP - 397
EP - 400
BT - 2006 Computers in Cardiology, CIC
T2 - 2006 Computers in Cardiology, CIC
Y2 - 17 September 2006 through 20 September 2006
ER -