Résumé
The expression of class II major histocompatibility complex (MHC) on rat intestinal intraepithelial lymphocytes (IELs) and mesenteric lymph node cells (MLNCs) were examined by immunofluorescence and flow cytometry. As expected, MLNCs contain eight small populations of CD4+ class II MHC+ T-cells in addition to classical antigen presenting cells. In contrast, rat IELs include a significant population of class II MHC+ T-cells, predominantly in the CD8+ CD4- αβTCR+ subset. IEL samples with a relatively high percentage of class II MHC+ cells also include some CD4+ class II MHC+ cells; IEL samples with a low percentage of class II MHC+ cells also include some CD4- CD8- class II MHC+ cells. The role of lymphocyte subpopulations in the intestinal epithelium may need to be revisited in consideration of these findings.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 63-68 |
| Nombre de pages | 6 |
| Journal | Immunology Letters |
| Volume | 55 |
| Numéro de publication | 2 |
| DOI | |
| Statut de publication | Published - févr. 1997 |
Note bibliographique
Funding Information:This study was supported by the Crohn’s and Colitis Foundation of Canada, and the Natural Sciences and Engineering Research Council of Canada. Dr Stadnyk is the recipient of an IWK Children’s Hospital Research Investigatorship. The authors thank Dr Linda Best for assistance with the flow cytometry.
ASJC Scopus Subject Areas
- Immunology and Allergy
- Immunology