Cyclooxygenase inhibitors protect d-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model

Medicine & Life Sciences

• Galactosamine 87%
• Cyclooxygenase Inhibitors 79%
• nimesulide 72%
• Lipopolysaccharides 56%
• Theoretical Models 53%
• Indomethacin 49%
• Cyclooxygenase 2 Inhibitors 38%
• Liver 34%
• Wounds and Injuries 32%
• 3-nitrotyrosine 21%
• Inbred ICR Mouse 20%
• Acute Liver Failure 19%
• Messenger RNA 18%
• Sepsis 13%
• Necrosis 12%
• Anti-Inflammatory Agents 12%
• Western Blotting 11%
• Polymerase Chain Reaction 9%
• Injections 9%
• Control Groups 8%
• Serum 7%
• Pharmaceutical Preparations 6%
• Proteins 6%
• Therapeutics 5%

Agriculture & Biology

• cyclooxygenase inhibitors 89%
• galactosamine 82%
• prostaglandin synthase 73%
• lipopolysaccharides 63%
• animal models 58%
• liver 38%
• indomethacin 36%
• mice 31%
• liver failure 17%
• anti-inflammatory agents 14%
• inducible nitric oxide synthase 13%
• hepatotoxicity 13%
• thiobarbituric acid-reactive substances 11%
• protective effect 10%
• necrosis 9%
• tissues 9%
• Western blotting 9%
• blood serum 8%
• reverse transcriptase polymerase chain reaction 8%
• pretreatment 8%
• injection 7%
• blood 6%
• dosage 5%

Chemical Compounds

• Nimesulide 100%
• EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthase) Inhibitor 99%
• Lipopolysaccharide 72%
• Nitrotyrosine 52%
• Anti-Inflammatory Drug 42%
• Protective 27%
• Dose 25%
• Reduction 15%
• Protein 13%