Regional differences in connexin32 and connexin43 messenger RNAs in rat brain

Christian C.G. Naus; Daniel J. Belliveau; John F. Bechberger

doi:10.1016/0304-3940(90)90278-H

Regional differences in connexin32 and connexin43 messenger RNAs in rat brain

Christian C.G. Naus, Daniel J. Belliveau, John F. Bechberger

Résultat de recherche: Article › examen par les pairs

43 Citations (Scopus)

Résumé

The regional distribution of gap junction mRNAs was examined in the adult rat brain. The level of connexin43 mRNA is more abundant than connexin32, being homogeneously distributed throughout different regions of brain. In contrast, there is dramatic heterogeneity in the level of connexin32 mRNA, with the highest level in the hindbrain. These results suggest that the gap junction genes are differentially expressed in regions of the adult rat brain.

Langue d'origine	English
Pages (de-à)	297-302
Nombre de pages	6
Journal	Neuroscience Letters
Volume	111
Numéro de publication	3
DOI	https://doi.org/10.1016/0304-3940(90)90278-H
Statut de publication	Published - avr. 6 1990
Publié à l'externe	Oui

Note bibliographique

Funding Information:
The authors are grateful to Dr. David Paul for his generous provision of the connexin cDNAs, and to Dr. D. Denhardt for the 18S cDNA used in this study. This research was supported by grants from the Hospital for Sick Children Foundation (Grant 88-05) and the Ministry of Community and Social Services, Ontario, Canada, administered by the Research and Program Evaluation Unit, in co-operation with the Ontario Mental Health Foundation, funded from the 'Interprovincial' Lottery Research Program. C.C.G.N. is a Scholar of the Medical Research Council of Canada, and D.J.B. is a holder of an NSERC Postgraduate Scholarship.

ASJC Scopus Subject Areas

General Neuroscience

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10.1016/0304-3940(90)90278-H

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abstract = "The regional distribution of gap junction mRNAs was examined in the adult rat brain. The level of connexin43 mRNA is more abundant than connexin32, being homogeneously distributed throughout different regions of brain. In contrast, there is dramatic heterogeneity in the level of connexin32 mRNA, with the highest level in the hindbrain. These results suggest that the gap junction genes are differentially expressed in regions of the adult rat brain.",

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note = "Funding Information: The authors are grateful to Dr. David Paul for his generous provision of the connexin cDNAs, and to Dr. D. Denhardt for the 18S cDNA used in this study. This research was supported by grants from the Hospital for Sick Children Foundation (Grant 88-05) and the Ministry of Community and Social Services, Ontario, Canada, administered by the Research and Program Evaluation Unit, in co-operation with the Ontario Mental Health Foundation, funded from the 'Interprovincial' Lottery Research Program. C.C.G.N. is a Scholar of the Medical Research Council of Canada, and D.J.B. is a holder of an NSERC Postgraduate Scholarship.",

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doi = "10.1016/0304-3940(90)90278-H",

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AU - Naus, Christian C.G.

AU - Belliveau, Daniel J.

AU - Bechberger, John F.

N1 - Funding Information: The authors are grateful to Dr. David Paul for his generous provision of the connexin cDNAs, and to Dr. D. Denhardt for the 18S cDNA used in this study. This research was supported by grants from the Hospital for Sick Children Foundation (Grant 88-05) and the Ministry of Community and Social Services, Ontario, Canada, administered by the Research and Program Evaluation Unit, in co-operation with the Ontario Mental Health Foundation, funded from the 'Interprovincial' Lottery Research Program. C.C.G.N. is a Scholar of the Medical Research Council of Canada, and D.J.B. is a holder of an NSERC Postgraduate Scholarship.

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N2 - The regional distribution of gap junction mRNAs was examined in the adult rat brain. The level of connexin43 mRNA is more abundant than connexin32, being homogeneously distributed throughout different regions of brain. In contrast, there is dramatic heterogeneity in the level of connexin32 mRNA, with the highest level in the hindbrain. These results suggest that the gap junction genes are differentially expressed in regions of the adult rat brain.

AB - The regional distribution of gap junction mRNAs was examined in the adult rat brain. The level of connexin43 mRNA is more abundant than connexin32, being homogeneously distributed throughout different regions of brain. In contrast, there is dramatic heterogeneity in the level of connexin32 mRNA, with the highest level in the hindbrain. These results suggest that the gap junction genes are differentially expressed in regions of the adult rat brain.

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Regional differences in connexin32 and connexin43 messenger RNAs in rat brain

Résumé

Note bibliographique

ASJC Scopus Subject Areas

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