α2-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat

John W. Downie; Mary Jane Espey; Jerzy B. Gajewski

doi:10.1016/0014-2999(91)90551-Z

α₂-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat

John W. Downie, Mary Jane Espey, Jerzy B. Gajewski

Medicine

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

In chloralose-anaesthetized cats, clonidine, an α₂-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α₂-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α₂-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α₂-adrenoceptors and is not dependent on an imidazole structure.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	European Journal of Pharmacology
Volume	195
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(91)90551-Z
Publication status	Published - Mar 26 1991

Bibliographical note

Funding Information:
The gifts of guanabenza cetate( Dr. Eric Naftchi. New York University)a nd SK&F 86466( Dr. Robert Willette. Smith Kline and French Laboratories)a re gratefullya cknowledgedT. his work was supportedb y the Medical ResearchC ouncil of Canada.D r. Gajewski was a CanadianU rologicalA ssociationS cholar.

ASJC Scopus Subject Areas

Pharmacology

Access to Document

10.1016/0014-2999(91)90551-Z

Cite this

@article{35bc31f092924164b0832297e3476a0b,

title = "α2-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat",

abstract = "In chloralose-anaesthetized cats, clonidine, an α2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α2-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α2-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α2-adrenoceptors and is not dependent on an imidazole structure.",

author = "Downie, {John W.} and Espey, {Mary Jane} and Gajewski, {Jerzy B.}",

note = "Funding Information: The gifts of guanabenza cetate( Dr. Eric Naftchi. New York University)a nd SK&F 86466( Dr. Robert Willette. Smith Kline and French Laboratories)a re gratefullya cknowledgedT. his work was supportedb y the Medical ResearchC ouncil of Canada.D r. Gajewski was a CanadianU rologicalA ssociationS cholar.",

year = "1991",

month = mar,

day = "26",

doi = "10.1016/0014-2999(91)90551-Z",

language = "English",

volume = "195",

pages = "301--304",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - α2-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat

AU - Downie, John W.

AU - Espey, Mary Jane

AU - Gajewski, Jerzy B.

N1 - Funding Information: The gifts of guanabenza cetate( Dr. Eric Naftchi. New York University)a nd SK&F 86466( Dr. Robert Willette. Smith Kline and French Laboratories)a re gratefullya cknowledgedT. his work was supportedb y the Medical ResearchC ouncil of Canada.D r. Gajewski was a CanadianU rologicalA ssociationS cholar.

PY - 1991/3/26

Y1 - 1991/3/26

N2 - In chloralose-anaesthetized cats, clonidine, an α2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α2-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α2-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α2-adrenoceptors and is not dependent on an imidazole structure.

AB - In chloralose-anaesthetized cats, clonidine, an α2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α2-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α2-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α2-adrenoceptors and is not dependent on an imidazole structure.

UR - http://www.scopus.com/inward/record.url?scp=0025979012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025979012&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(91)90551-Z

DO - 10.1016/0014-2999(91)90551-Z

M3 - Article

C2 - 1678710

AN - SCOPUS:0025979012

SN - 0014-2999

VL - 195

SP - 301

EP - 304

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -