α2-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat

John W. Downie; Mary Jane Espey; Jerzy B. Gajewski

doi:10.1016/0014-2999(91)90551-Z

α₂-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat

John W. Downie, Mary Jane Espey, Jerzy B. Gajewski

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

28 Citations (Scopus)

Résumé

In chloralose-anaesthetized cats, clonidine, an α₂-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α₂-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α₂-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α₂-adrenoceptors and is not dependent on an imidazole structure.

Langue d'origine	English
Pages (de-à)	301-304
Nombre de pages	4
Journal	European Journal of Pharmacology
Volume	195
Numéro de publication	2
DOI	https://doi.org/10.1016/0014-2999(91)90551-Z
Statut de publication	Published - mars 26 1991

Note bibliographique

Funding Information:
The gifts of guanabenza cetate( Dr. Eric Naftchi. New York University)a nd SK&F 86466( Dr. Robert Willette. Smith Kline and French Laboratories)a re gratefullya cknowledgedT. his work was supportedb y the Medical ResearchC ouncil of Canada.D r. Gajewski was a CanadianU rologicalA ssociationS cholar.

ASJC Scopus Subject Areas

Pharmacology

Accès au document

10.1016/0014-2999(91)90551-Z

Autres fichiers et liens

Citer

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abstract = "In chloralose-anaesthetized cats, clonidine, an α2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α2-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α2-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α2-adrenoceptors and is not dependent on an imidazole structure.",

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AB - In chloralose-anaesthetized cats, clonidine, an α2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α2-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α2-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α2-adrenoceptors and is not dependent on an imidazole structure.

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