α2-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat

John W. Downie; Mary Jane Espey; Jerzy B. Gajewski

doi:10.1016/0014-2999(91)90551-Z

α₂-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat

John W. Downie, Mary Jane Espey, Jerzy B. Gajewski

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

28 Citas (Scopus)

Resumen

In chloralose-anaesthetized cats, clonidine, an α₂-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α₂-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α₂-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α₂-adrenoceptors and is not dependent on an imidazole structure.

Idioma original	English
Páginas (desde-hasta)	301-304
Número de páginas	4
Publicación	European Journal of Pharmacology
Volumen	195
N.º	2
DOI	https://doi.org/10.1016/0014-2999(91)90551-Z
Estado	Published - mar. 26 1991

Nota bibliográfica

Funding Information:
The gifts of guanabenza cetate( Dr. Eric Naftchi. New York University)a nd SK&F 86466( Dr. Robert Willette. Smith Kline and French Laboratories)a re gratefullya cknowledgedT. his work was supportedb y the Medical ResearchC ouncil of Canada.D r. Gajewski was a CanadianU rologicalA ssociationS cholar.

ASJC Scopus Subject Areas

Pharmacology

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10.1016/0014-2999(91)90551-Z

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abstract = "In chloralose-anaesthetized cats, clonidine, an α2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole α2-adrenoceptor agonist, and was reversed by SK&F 86466, a non-imidazole α2-adrenoceptor antagonist. These results imply clonidine's action on this reflex related to urinary sphincter function is mediated by α2-adrenoceptors and is not dependent on an imidazole structure.",

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