A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

Ann Karen C. Brassinga; Margot F. Hiltz; Gary R. Sisson; Michael G. Morash; Nathan Hill; Elizabeth Garduno; Paul H. Edelstein; Rafael A. Garduno; Paul S. Hoffman

doi:10.1128/JB.185.15.4630-4637.2003

A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

Ann Karen C. Brassinga, Margot F. Hiltz, Gary R. Sisson, Michael G. Morash, Nathan Hill, Elizabeth Garduno, Paul H. Edelstein, Rafael A. Garduno, Paul S. Hoffman

Medicine

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this ∼65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

Original language	English
Pages (from-to)	4630-4637
Number of pages	8
Journal	Journal of Bacteriology
Volume	185
Issue number	15
DOIs	https://doi.org/10.1128/JB.185.15.4630-4637.2003
Publication status	Published - Aug 2003

ASJC Scopus Subject Areas

Microbiology
Molecular Biology

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10.1128/JB.185.15.4630-4637.2003

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title = "A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila",

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AU - Brassinga, Ann Karen C.

AU - Hiltz, Margot F.

AU - Sisson, Gary R.

AU - Morash, Michael G.

AU - Hill, Nathan

AU - Garduno, Elizabeth

AU - Edelstein, Paul H.

AU - Garduno, Rafael A.

AU - Hoffman, Paul S.

PY - 2003/8

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AB - Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this ∼65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

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A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

Abstract

ASJC Scopus Subject Areas

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