A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

Ann Karen C. Brassinga; Margot F. Hiltz; Gary R. Sisson; Michael G. Morash; Nathan Hill; Elizabeth Garduno; Paul H. Edelstein; Rafael A. Garduno; Paul S. Hoffman

doi:10.1128/JB.185.15.4630-4637.2003

A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

Ann Karen C. Brassinga, Margot F. Hiltz, Gary R. Sisson, Michael G. Morash, Nathan Hill, Elizabeth Garduno, Paul H. Edelstein, Rafael A. Garduno, Paul S. Hoffman

Medicine

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47 Citations (Scopus)

Résumé

Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this ∼65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

Langue d'origine	English
Pages (de-à)	4630-4637
Nombre de pages	8
Journal	Journal of Bacteriology
Volume	185
Numéro de publication	15
DOI	https://doi.org/10.1128/JB.185.15.4630-4637.2003
Statut de publication	Published - août 2003

ASJC Scopus Subject Areas

Microbiology
Molecular Biology

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10.1128/JB.185.15.4630-4637.2003

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abstract = "Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this ∼65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.",

author = "Brassinga, {Ann Karen C.} and Hiltz, {Margot F.} and Sisson, {Gary R.} and Morash, {Michael G.} and Nathan Hill and Elizabeth Garduno and Edelstein, {Paul H.} and Garduno, {Rafael A.} and Hoffman, {Paul S.}",

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AU - Brassinga, Ann Karen C.

AU - Hiltz, Margot F.

AU - Sisson, Gary R.

AU - Morash, Michael G.

AU - Hill, Nathan

AU - Garduno, Elizabeth

AU - Edelstein, Paul H.

AU - Garduno, Rafael A.

AU - Hoffman, Paul S.

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Y1 - 2003/8

N2 - Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this ∼65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

AB - Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this ∼65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

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A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

Résumé

ASJC Scopus Subject Areas

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