A comparison of I125 Clq binding, Raji cell binding, and lymphocytotoxic activity in multiple sclerosis

Alan L. Schocket; Ronald I. Carr; Melissa A. Hardtke

doi:10.1016/0090-1229(80)90120-8

A comparison of I¹²⁵ Clq binding, Raji cell binding, and lymphocytotoxic activity in multiple sclerosis

Alan L. Schocket, Ronald I. Carr, Melissa A. Hardtke

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Sera from 48 patients with chronic multiple sclerosis (MS) were examined for the presence of immune complexes using both the I¹²⁵ Clq binding assay and the Raji cell assay. Lymphocytotoxic antibodies were also measured. Circulating complexes were found in only four patients by both assays. There was complete agreement between the two assays and no relationship between the presence of immune complexes and lymphocytotoxic antibodies. The results of this study fail to show a significant increase in circulating immune complexes in our patients with MS.

Original language	English
Pages (from-to)	477-481
Number of pages	5
Journal	Clinical Immunology and Immunopathology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0090-1229(80)90120-8
Publication status	Published - 1980
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

PubMed: MeSH publication types

Comparative Study
Journal Article

Access to Document

10.1016/0090-1229(80)90120-8

Cite this

@article{8052aaaeb6fa42f2b35c202b3b3a782b,

title = "A comparison of I125 Clq binding, Raji cell binding, and lymphocytotoxic activity in multiple sclerosis",

abstract = "Sera from 48 patients with chronic multiple sclerosis (MS) were examined for the presence of immune complexes using both the I125 Clq binding assay and the Raji cell assay. Lymphocytotoxic antibodies were also measured. Circulating complexes were found in only four patients by both assays. There was complete agreement between the two assays and no relationship between the presence of immune complexes and lymphocytotoxic antibodies. The results of this study fail to show a significant increase in circulating immune complexes in our patients with MS.",

author = "Schocket, {Alan L.} and Carr, {Ronald I.} and Hardtke, {Melissa A.}",

year = "1980",

doi = "10.1016/0090-1229(80)90120-8",

language = "English",

volume = "17",

pages = "477--481",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - A comparison of I125 Clq binding, Raji cell binding, and lymphocytotoxic activity in multiple sclerosis

AU - Schocket, Alan L.

AU - Carr, Ronald I.

AU - Hardtke, Melissa A.

PY - 1980

Y1 - 1980

N2 - Sera from 48 patients with chronic multiple sclerosis (MS) were examined for the presence of immune complexes using both the I125 Clq binding assay and the Raji cell assay. Lymphocytotoxic antibodies were also measured. Circulating complexes were found in only four patients by both assays. There was complete agreement between the two assays and no relationship between the presence of immune complexes and lymphocytotoxic antibodies. The results of this study fail to show a significant increase in circulating immune complexes in our patients with MS.

AB - Sera from 48 patients with chronic multiple sclerosis (MS) were examined for the presence of immune complexes using both the I125 Clq binding assay and the Raji cell assay. Lymphocytotoxic antibodies were also measured. Circulating complexes were found in only four patients by both assays. There was complete agreement between the two assays and no relationship between the presence of immune complexes and lymphocytotoxic antibodies. The results of this study fail to show a significant increase in circulating immune complexes in our patients with MS.

UR - http://www.scopus.com/inward/record.url?scp=0018911225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018911225&partnerID=8YFLogxK

U2 - 10.1016/0090-1229(80)90120-8

DO - 10.1016/0090-1229(80)90120-8

M3 - Article

C2 - 7428189

AN - SCOPUS:0018911225

SN - 0090-1229

VL - 17

SP - 477

EP - 481

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 3

ER -