A comparison of I125 Clq binding, Raji cell binding, and lymphocytotoxic activity in multiple sclerosis

Alan L. Schocket; Ronald I. Carr; Melissa A. Hardtke

doi:10.1016/0090-1229(80)90120-8

A comparison of I¹²⁵ Clq binding, Raji cell binding, and lymphocytotoxic activity in multiple sclerosis

Alan L. Schocket, Ronald I. Carr, Melissa A. Hardtke

Résultat de recherche: Article › examen par les pairs

13 Citations (Scopus)

Résumé

Sera from 48 patients with chronic multiple sclerosis (MS) were examined for the presence of immune complexes using both the I¹²⁵ Clq binding assay and the Raji cell assay. Lymphocytotoxic antibodies were also measured. Circulating complexes were found in only four patients by both assays. There was complete agreement between the two assays and no relationship between the presence of immune complexes and lymphocytotoxic antibodies. The results of this study fail to show a significant increase in circulating immune complexes in our patients with MS.

Langue d'origine	English
Pages (de-à)	477-481
Nombre de pages	5
Journal	Clinical Immunology and Immunopathology
Volume	17
Numéro de publication	3
DOI	https://doi.org/10.1016/0090-1229(80)90120-8
Statut de publication	Published - 1980
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

PubMed: MeSH publication types

Comparative Study
Journal Article

Accès au document

10.1016/0090-1229(80)90120-8

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abstract = "Sera from 48 patients with chronic multiple sclerosis (MS) were examined for the presence of immune complexes using both the I125 Clq binding assay and the Raji cell assay. Lymphocytotoxic antibodies were also measured. Circulating complexes were found in only four patients by both assays. There was complete agreement between the two assays and no relationship between the presence of immune complexes and lymphocytotoxic antibodies. The results of this study fail to show a significant increase in circulating immune complexes in our patients with MS.",

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AU - Schocket, Alan L.

AU - Carr, Ronald I.

AU - Hardtke, Melissa A.

PY - 1980

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AB - Sera from 48 patients with chronic multiple sclerosis (MS) were examined for the presence of immune complexes using both the I125 Clq binding assay and the Raji cell assay. Lymphocytotoxic antibodies were also measured. Circulating complexes were found in only four patients by both assays. There was complete agreement between the two assays and no relationship between the presence of immune complexes and lymphocytotoxic antibodies. The results of this study fail to show a significant increase in circulating immune complexes in our patients with MS.

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