Comparative genomic hybridization and array based CGH in cancer

Roland Hubaux; Victor D. Martinez; David Rowbotham; Wan L. Lam

doi:10.1007/978-1-4899-8050-2_3

Comparative genomic hybridization and array based CGH in cancer

Roland Hubaux, Victor D. Martinez, David Rowbotham, Wan L. Lam

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Genomic instability is a key feature of cancer. Chromosomal rearrangements and segmental DNA copy-number alterations in the tumor genome lead to aberrant gene expression pattern. Array-based comparative genomic hybridization (aCGH) is a molecular cytogenetic technique designed to measure DNA copy-number status and identify segmental dosage alterations. The emergence of aCGH technology is placed into context in the evolution of molecular cytogenetics. The defining characteristics of contemporary genomic array platforms are reviewed, and the material considerations for using these platforms are explained. This chapter describes the development and current knowledge on aCGH technology and its role in cancer research and clinical diagnostics.

Original language	English
Title of host publication	Molecular Testing in Cancer
Publisher	Springer New York
Pages	27-37
Number of pages	11
ISBN (Electronic)	9781489980502
ISBN (Print)	1489980490, 9781489980496
DOIs	https://doi.org/10.1007/978-1-4899-8050-2_3
Publication status	Published - Oct 1 2013
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Springer Science+Business Media New York. All rights are reserved.

ASJC Scopus Subject Areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4899-8050-2_3

Cite this

@inbook{7fac7ce4012848669244f55652956aba,

title = "Comparative genomic hybridization and array based CGH in cancer",

abstract = "Genomic instability is a key feature of cancer. Chromosomal rearrangements and segmental DNA copy-number alterations in the tumor genome lead to aberrant gene expression pattern. Array-based comparative genomic hybridization (aCGH) is a molecular cytogenetic technique designed to measure DNA copy-number status and identify segmental dosage alterations. The emergence of aCGH technology is placed into context in the evolution of molecular cytogenetics. The defining characteristics of contemporary genomic array platforms are reviewed, and the material considerations for using these platforms are explained. This chapter describes the development and current knowledge on aCGH technology and its role in cancer research and clinical diagnostics.",

author = "Roland Hubaux and Martinez, {Victor D.} and David Rowbotham and Lam, {Wan L.}",

note = "Publisher Copyright: {\textcopyright} 2014 Springer Science+Business Media New York. All rights are reserved.",

year = "2013",

month = oct,

day = "1",

doi = "10.1007/978-1-4899-8050-2_3",

language = "English",

isbn = "1489980490",

pages = "27--37",

booktitle = "Molecular Testing in Cancer",

publisher = "Springer New York",

address = "United States",

}

TY - CHAP

T1 - Comparative genomic hybridization and array based CGH in cancer

AU - Hubaux, Roland

AU - Martinez, Victor D.

AU - Rowbotham, David

AU - Lam, Wan L.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Genomic instability is a key feature of cancer. Chromosomal rearrangements and segmental DNA copy-number alterations in the tumor genome lead to aberrant gene expression pattern. Array-based comparative genomic hybridization (aCGH) is a molecular cytogenetic technique designed to measure DNA copy-number status and identify segmental dosage alterations. The emergence of aCGH technology is placed into context in the evolution of molecular cytogenetics. The defining characteristics of contemporary genomic array platforms are reviewed, and the material considerations for using these platforms are explained. This chapter describes the development and current knowledge on aCGH technology and its role in cancer research and clinical diagnostics.

AB - Genomic instability is a key feature of cancer. Chromosomal rearrangements and segmental DNA copy-number alterations in the tumor genome lead to aberrant gene expression pattern. Array-based comparative genomic hybridization (aCGH) is a molecular cytogenetic technique designed to measure DNA copy-number status and identify segmental dosage alterations. The emergence of aCGH technology is placed into context in the evolution of molecular cytogenetics. The defining characteristics of contemporary genomic array platforms are reviewed, and the material considerations for using these platforms are explained. This chapter describes the development and current knowledge on aCGH technology and its role in cancer research and clinical diagnostics.

UR - http://www.scopus.com/inward/record.url?scp=84930077340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930077340&partnerID=8YFLogxK

U2 - 10.1007/978-1-4899-8050-2_3

DO - 10.1007/978-1-4899-8050-2_3

M3 - Chapter

AN - SCOPUS:84930077340

SN - 1489980490

SN - 9781489980496

SP - 27

EP - 37

BT - Molecular Testing in Cancer

PB - Springer New York

ER -

Comparative genomic hybridization and array based CGH in cancer

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this