Comparative genomic hybridization and array based CGH in cancer

Roland Hubaux; Victor D. Martinez; David Rowbotham; Wan L. Lam

doi:10.1007/978-1-4899-8050-2_3

Comparative genomic hybridization and array based CGH in cancer

Roland Hubaux, Victor D. Martinez, David Rowbotham, Wan L. Lam

Résultat de recherche: Chapter

Résumé

Genomic instability is a key feature of cancer. Chromosomal rearrangements and segmental DNA copy-number alterations in the tumor genome lead to aberrant gene expression pattern. Array-based comparative genomic hybridization (aCGH) is a molecular cytogenetic technique designed to measure DNA copy-number status and identify segmental dosage alterations. The emergence of aCGH technology is placed into context in the evolution of molecular cytogenetics. The defining characteristics of contemporary genomic array platforms are reviewed, and the material considerations for using these platforms are explained. This chapter describes the development and current knowledge on aCGH technology and its role in cancer research and clinical diagnostics.

Langue d'origine	English
Titre de la publication principale	Molecular Testing in Cancer
Maison d'édition	Springer New York
Pages	27-37
Nombre de pages	11
ISBN (électronique)	9781489980502
ISBN (imprimé)	1489980490, 9781489980496
DOI	https://doi.org/10.1007/978-1-4899-8050-2_3
Statut de publication	Published - oct. 1 2013
Publié à l'externe	Oui

Note bibliographique

Publisher Copyright:
© 2014 Springer Science+Business Media New York. All rights are reserved.

ASJC Scopus Subject Areas

General Medicine

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1007/978-1-4899-8050-2_3

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Comparative genomic hybridization and array based CGH in cancer

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

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