Comparative genomic hybridization and array based CGH in cancer

Roland Hubaux; Victor D. Martinez; David Rowbotham; Wan L. Lam

doi:10.1007/978-1-4899-8050-2_3

Comparative genomic hybridization and array based CGH in cancer

Roland Hubaux, Victor D. Martinez, David Rowbotham, Wan L. Lam

Producción científica: Capítulo en Libro/Reporte/Acta de conferencia › Capítulo

Resumen

Genomic instability is a key feature of cancer. Chromosomal rearrangements and segmental DNA copy-number alterations in the tumor genome lead to aberrant gene expression pattern. Array-based comparative genomic hybridization (aCGH) is a molecular cytogenetic technique designed to measure DNA copy-number status and identify segmental dosage alterations. The emergence of aCGH technology is placed into context in the evolution of molecular cytogenetics. The defining characteristics of contemporary genomic array platforms are reviewed, and the material considerations for using these platforms are explained. This chapter describes the development and current knowledge on aCGH technology and its role in cancer research and clinical diagnostics.

Idioma original	English
Título de la publicación alojada	Molecular Testing in Cancer
Editorial	Springer New York
Páginas	27-37
Número de páginas	11
ISBN (versión digital)	9781489980502
ISBN (versión impresa)	1489980490, 9781489980496
DOI	https://doi.org/10.1007/978-1-4899-8050-2_3
Estado	Published - oct. 1 2013
Publicado de forma externa	Sí

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© 2014 Springer Science+Business Media New York. All rights are reserved.

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General Medicine

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Comparative genomic hybridization and array based CGH in cancer

Resumen

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ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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