Connecting reovirus oncolysis and ras signaling

Paola Marcato; Maya Shmulevitz; Patrick W. Lee

doi:10.4161/cc.4.4.1600

Connecting reovirus oncolysis and ras signaling

Paola Marcato, Maya Shmulevitz, Patrick W. Lee

Medicine

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.

Original language	English
Pages (from-to)	556
Number of pages	1
Journal	Cell Cycle
Volume	4
Issue number	4
DOIs	https://doi.org/10.4161/cc.4.4.1600
Publication status	Published - Apr 2005

ASJC Scopus Subject Areas

Molecular Biology
Developmental Biology
Cell Biology

PubMed: MeSH publication types

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cc.4.4.1600

Cite this

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AB - Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.

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Connecting reovirus oncolysis and ras signaling

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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