Connecting reovirus oncolysis and ras signaling

Paola Marcato; Maya Shmulevitz; Patrick W. Lee

doi:10.4161/cc.4.4.1600

Connecting reovirus oncolysis and ras signaling

Paola Marcato, Maya Shmulevitz, Patrick W. Lee

Medicine

Résultat de recherche: Review article › examen par les pairs

34 Citations (Scopus)

Résumé

Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.

Langue d'origine	English
Pages (de-à)	556
Nombre de pages	1
Journal	Cell Cycle
Volume	4
Numéro de publication	4
DOI	https://doi.org/10.4161/cc.4.4.1600
Statut de publication	Published - avr. 2005

ASJC Scopus Subject Areas

Molecular Biology
Developmental Biology
Cell Biology

PubMed: MeSH publication types

Journal Article
Review

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.4161/cc.4.4.1600

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AB - Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.

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Connecting reovirus oncolysis and ras signaling

Résumé

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer