Connecting reovirus oncolysis and ras signaling

Paola Marcato; Maya Shmulevitz; Patrick W. Lee

doi:10.4161/cc.4.4.1600

Connecting reovirus oncolysis and ras signaling

Paola Marcato, Maya Shmulevitz, Patrick W. Lee

Medicine

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

34 Citas (Scopus)

Resumen

Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.

Idioma original	English
Páginas (desde-hasta)	556
Número de páginas	1
Publicación	Cell Cycle
Volumen	4
N.º	4
DOI	https://doi.org/10.4161/cc.4.4.1600
Estado	Published - abr. 2005

ASJC Scopus Subject Areas

Molecular Biology
Developmental Biology
Cell Biology

PubMed: MeSH publication types

Journal Article
Review

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.4161/cc.4.4.1600

Otros archivos y enlaces

Citar esto

@article{856b778012a745dcbd111d420b8a5096,

title = "Connecting reovirus oncolysis and ras signaling",

abstract = "Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.",

author = "Paola Marcato and Maya Shmulevitz and Lee, {Patrick W.}",

year = "2005",

month = apr,

doi = "10.4161/cc.4.4.1600",

language = "English",

volume = "4",

pages = "556",

journal = "Cell Cycle",

issn = "1538-4101",

publisher = "Landes Bioscience",

number = "4",

}

TY - JOUR

T1 - Connecting reovirus oncolysis and ras signaling

AU - Marcato, Paola

AU - Shmulevitz, Maya

AU - Lee, Patrick W.

PY - 2005/4

Y1 - 2005/4

N2 - Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.

AB - Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.

UR - http://www.scopus.com/inward/record.url?scp=25444453229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444453229&partnerID=8YFLogxK

U2 - 10.4161/cc.4.4.1600

DO - 10.4161/cc.4.4.1600

M3 - Review article

C2 - 15753655

AN - SCOPUS:25444453229

SN - 1538-4101

VL - 4

SP - 556

JO - Cell Cycle

JF - Cell Cycle

IS - 4

ER -

Connecting reovirus oncolysis and ras signaling

Resumen

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto