Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Jeremy J. Walsh; Brittany A. Edgett; Michael E. Tschakovsky; Brendon J. Gurd

doi:10.1139/apnm-2014-0290

Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Jeremy J. Walsh, Brittany A. Edgett, Michael E. Tschakovsky, Brendon J. Gurd

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

Original language	English
Pages (from-to)	96-98
Number of pages	3
Journal	Applied Physiology, Nutrition and Metabolism
Volume	40
Issue number	1
DOIs	https://doi.org/10.1139/apnm-2014-0290
Publication status	Published - Sept 5 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015, National Research Council of Canada. All rights reserved.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Physiology
Nutrition and Dietetics
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1139/apnm-2014-0290

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abstract = "Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.",

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AU - Tschakovsky, Michael E.

AU - Gurd, Brendon J.

PY - 2014/9/5

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AB - Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

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Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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