Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Jeremy J. Walsh; Brittany A. Edgett; Michael E. Tschakovsky; Brendon J. Gurd

doi:10.1139/apnm-2014-0290

Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Jeremy J. Walsh, Brittany A. Edgett, Michael E. Tschakovsky, Brendon J. Gurd

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29 Citas (Scopus)

Resumen

Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

Idioma original	English
Páginas (desde-hasta)	96-98
Número de páginas	3
Publicación	Applied Physiology, Nutrition and Metabolism
Volumen	40
N.º	1
DOI	https://doi.org/10.1139/apnm-2014-0290
Estado	Published - sep. 5 2014
Publicado de forma externa	Sí

Nota bibliográfica

Publisher Copyright:
© 2015, National Research Council of Canada. All rights reserved.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Physiology
Nutrition and Dietetics
Physiology (medical)

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PY - 2014/9/5

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AB - Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

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Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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