Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Jeremy J. Walsh; Brittany A. Edgett; Michael E. Tschakovsky; Brendon J. Gurd

doi:10.1139/apnm-2014-0290

Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Jeremy J. Walsh, Brittany A. Edgett, Michael E. Tschakovsky, Brendon J. Gurd

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29 Citations (Scopus)

Résumé

Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

Langue d'origine	English
Pages (de-à)	96-98
Nombre de pages	3
Journal	Applied Physiology, Nutrition and Metabolism
Volume	40
Numéro de publication	1
DOI	https://doi.org/10.1139/apnm-2014-0290
Statut de publication	Published - sept. 5 2014
Publié à l'externe	Oui

Note bibliographique

Publisher Copyright:
© 2015, National Research Council of Canada. All rights reserved.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Physiology
Nutrition and Dietetics
Physiology (medical)

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1139/apnm-2014-0290

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abstract = "Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.",

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AU - Edgett, Brittany A.

AU - Tschakovsky, Michael E.

AU - Gurd, Brendon J.

PY - 2014/9/5

Y1 - 2014/9/5

N2 - Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

AB - Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

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Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

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