TY - JOUR
T1 - Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan
AU - Kind, Leon S.
PY - 1953/1
Y1 - 1953/1
N2 - Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.
AB - Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.
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U2 - 10.1016/0021-8707(53)90060-4
DO - 10.1016/0021-8707(53)90060-4
M3 - Article
C2 - 13022215
AN - SCOPUS:50449111625
SN - 0021-8707
VL - 24
SP - 52
EP - 59
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -
