Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1953
Externally publishedYes

ASJC Scopus Subject Areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan'. Together they form a unique fingerprint.

Cite this