Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan

Leon S. Kind

doi:10.1016/0021-8707(53)90060-4

Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan

Leon S. Kind

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Resumen

Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.

Idioma original	English
Páginas (desde-hasta)	52-59
Número de páginas	8
Publicación	Journal of Allergy and Clinical Immunology
Volumen	24
N.º	1
DOI	https://doi.org/10.1016/0021-8707(53)90060-4
Estado	Published - ene. 1953
Publicado de forma externa	Sí

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abstract = "Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.",

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AB - Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.

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Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan

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