Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan

Leon S. Kind

doi:10.1016/0021-8707(53)90060-4

Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan

Leon S. Kind

Résultat de recherche: Article › examen par les pairs

3 Citations (Scopus)

Résumé

Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.

Langue d'origine	English
Pages (de-à)	52-59
Nombre de pages	8
Journal	Journal of Allergy and Clinical Immunology
Volume	24
Numéro de publication	1
DOI	https://doi.org/10.1016/0021-8707(53)90060-4
Statut de publication	Published - janv. 1953
Publié à l'externe	Oui

ASJC Scopus Subject Areas

General Medicine

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1016/0021-8707(53)90060-4

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abstract = "Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.",

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AB - Cortisone inhibited the lethal effects of both histamine and H. pertussis vaccine in pertussis-inoculated mice. Cortisone also protected uninoculated mice from toxic death due to H. pertussis vaccine. The antihistamine, Neoantergan, protected pertussis-sensitized mice from the lethal effects of histamine but not from fatal amounts of H. pertussis vaccine. The advantages of using pertussis-inoculated, histamine-sensitive mice rather than guinea pigs in the screening of compounds which might be active against histamine are discussed.

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Inhibition of histamine death in pertussis-inoculated mice by cortisone and neoantergan

Résumé

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

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