Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

D. J. Bast; J. C.S. De Azavedo; T. Y. Tam; L. Kilburn; C. Duncan; L. A. Mandell; R. J. Davidson; D. E. Low

doi:10.1128/AAC.45.9.2631-2634.2001

Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

D. J. Bast, J. C.S. De Azavedo, T. Y. Tam, L. Kilburn, C. Duncan, L. A. Mandell, R. J. Davidson, D. E. Low

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

Original language	English
Pages (from-to)	2631-2634
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Issue number	9
DOIs	https://doi.org/10.1128/AAC.45.9.2631-2634.2001
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/AAC.45.9.2631-2634.2001

Cite this

@article{cc64434e08df4f749cd4dfa5dd2fb7c1,

title = "Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae",

abstract = "Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.",

author = "Bast, {D. J.} and {De Azavedo}, {J. C.S.} and Tam, {T. Y.} and L. Kilburn and C. Duncan and Mandell, {L. A.} and Davidson, {R. J.} and Low, {D. E.}",

year = "2001",

doi = "10.1128/AAC.45.9.2631-2634.2001",

language = "English",

volume = "45",

pages = "2631--2634",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

AU - Bast, D. J.

AU - De Azavedo, J. C.S.

AU - Tam, T. Y.

AU - Kilburn, L.

AU - Duncan, C.

AU - Mandell, L. A.

AU - Davidson, R. J.

AU - Low, D. E.

PY - 2001

Y1 - 2001

N2 - Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

AB - Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

UR - http://www.scopus.com/inward/record.url?scp=0034869512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034869512&partnerID=8YFLogxK

U2 - 10.1128/AAC.45.9.2631-2634.2001

DO - 10.1128/AAC.45.9.2631-2634.2001

M3 - Article

C2 - 11502541

AN - SCOPUS:0034869512

SN - 0066-4804

VL - 45

SP - 2631

EP - 2634

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

ER -

Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this