Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

D. J. Bast; J. C.S. De Azavedo; T. Y. Tam; L. Kilburn; C. Duncan; L. A. Mandell; R. J. Davidson; D. E. Low

doi:10.1128/AAC.45.9.2631-2634.2001

Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

D. J. Bast, J. C.S. De Azavedo, T. Y. Tam, L. Kilburn, C. Duncan, L. A. Mandell, R. J. Davidson, D. E. Low

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21 Citas (Scopus)

Resumen

Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

Idioma original	English
Páginas (desde-hasta)	2631-2634
Número de páginas	4
Publicación	Antimicrobial Agents and Chemotherapy
Volumen	45
N.º	9
DOI	https://doi.org/10.1128/AAC.45.9.2631-2634.2001
Estado	Published - 2001
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

PubMed: MeSH publication types

Journal Article
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abstract = "Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.",

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AU - Bast, D. J.

AU - De Azavedo, J. C.S.

AU - Tam, T. Y.

AU - Kilburn, L.

AU - Duncan, C.

AU - Mandell, L. A.

AU - Davidson, R. J.

AU - Low, D. E.

PY - 2001

Y1 - 2001

N2 - Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

AB - Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

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Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

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