Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

D. J. Bast; J. C.S. De Azavedo; T. Y. Tam; L. Kilburn; C. Duncan; L. A. Mandell; R. J. Davidson; D. E. Low

doi:10.1128/AAC.45.9.2631-2634.2001

Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

D. J. Bast, J. C.S. De Azavedo, T. Y. Tam, L. Kilburn, C. Duncan, L. A. Mandell, R. J. Davidson, D. E. Low

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21 Citations (Scopus)

Résumé

Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

Langue d'origine	English
Pages (de-à)	2631-2634
Nombre de pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Numéro de publication	9
DOI	https://doi.org/10.1128/AAC.45.9.2631-2634.2001
Statut de publication	Published - 2001
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1128/AAC.45.9.2631-2634.2001

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abstract = "Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.",

author = "Bast, {D. J.} and {De Azavedo}, {J. C.S.} and Tam, {T. Y.} and L. Kilburn and C. Duncan and Mandell, {L. A.} and Davidson, {R. J.} and Low, {D. E.}",

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AU - Bast, D. J.

AU - De Azavedo, J. C.S.

AU - Tam, T. Y.

AU - Kilburn, L.

AU - Duncan, C.

AU - Mandell, L. A.

AU - Davidson, R. J.

AU - Low, D. E.

PY - 2001

Y1 - 2001

N2 - Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

AB - Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

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Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

Résumé

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

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