Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Florian Guisier; Mateus Camargo Barros-Filho; Leigha D. Rock; Megan Strachan-Whaley; Erin A. Marshall; Graham Dellaire; Wan L. Lam

doi:10.1007/978-3-030-35723-8_3

Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Florian Guisier, Mateus Camargo Barros-Filho, Leigha D. Rock, Megan Strachan-Whaley, Erin A. Marshall, Graham Dellaire, Wan L. Lam

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Citations (Scopus)

Abstract

CD4+ T helper (T_H) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, naïve T_H cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector T_H cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of T_H cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	35-51
Number of pages	17
DOIs	https://doi.org/10.1007/978-3-030-35723-8_3
Publication status	Published - 2020

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1224
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Bibliographical note

Funding Information:
This work was supported by grants from the Canadian Institutes of Health Research (CIHR FDN-143345 to W.L.L. and PJT-156017 to G.D.) and scholarships from CIHR, Vanier Canada, and the BC Cancer Foundation. F.G. is supported by the Ligue nationale contre le cancer (Paris, France), the Fonds de Recherche en Santé Respiratoire (appel d’offres 2018 emis en commun avec la Fondation du Souffle, Paris, France), ADIR Association and the Foundation Charles Nicolle (Rouen, France). M.C.B.-F. is supported by the São Paulo Research Foundation (FAPESP 2015/17707-5 and 2018/06138-8). L.D.R. is supported by the BC Cancer Foundation and the University of British Columbia, Faculty of Dentistry. E.A.M. is supported by CIHR and the UBC, Faculty of Medicine and is a Vanier Canada Graduate scholar. G.D. is a senior scientist of the Beatrice Hunter Cancer Research Institute (BHCRI), and M.S.-W. is a trainee in the Cancer Research Training Program of the BHCRI, with funds provided by the QEII Health Sciences Centre Foundation and GIVETOLIVE.

Publisher Copyright:
© 2020, Springer Nature Switzerland AG.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

PubMed: MeSH publication types

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-030-35723-8_3

Cite this

Guisier, F., Barros-Filho, M. C., Rock, L. D., Strachan-Whaley, M., Marshall, E. A., Dellaire, G., & Lam, W. L. (2020). Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment. In Advances in Experimental Medicine and Biology (pp. 35-51). (Advances in Experimental Medicine and Biology; Vol. 1224). Springer. https://doi.org/10.1007/978-3-030-35723-8_3

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abstract = "CD4+ T helper (TH) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, na{\"i}ve TH cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector TH cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of TH cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators.",

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note = "Funding Information: This work was supported by grants from the Canadian Institutes of Health Research (CIHR FDN-143345 to W.L.L. and PJT-156017 to G.D.) and scholarships from CIHR, Vanier Canada, and the BC Cancer Foundation. F.G. is supported by the Ligue nationale contre le cancer (Paris, France), the Fonds de Recherche en Sant{\'e} Respiratoire (appel d{\textquoteright}offres 2018 emis en commun avec la Fondation du Souffle, Paris, France), ADIR Association and the Foundation Charles Nicolle (Rouen, France). M.C.B.-F. is supported by the S{\~a}o Paulo Research Foundation (FAPESP 2015/17707-5 and 2018/06138-8). L.D.R. is supported by the BC Cancer Foundation and the University of British Columbia, Faculty of Dentistry. E.A.M. is supported by CIHR and the UBC, Faculty of Medicine and is a Vanier Canada Graduate scholar. G.D. is a senior scientist of the Beatrice Hunter Cancer Research Institute (BHCRI), and M.S.-W. is a trainee in the Cancer Research Training Program of the BHCRI, with funds provided by the QEII Health Sciences Centre Foundation and GIVETOLIVE. Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG.",

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AU - Marshall, Erin A.

AU - Dellaire, Graham

AU - Lam, Wan L.

N1 - Funding Information: This work was supported by grants from the Canadian Institutes of Health Research (CIHR FDN-143345 to W.L.L. and PJT-156017 to G.D.) and scholarships from CIHR, Vanier Canada, and the BC Cancer Foundation. F.G. is supported by the Ligue nationale contre le cancer (Paris, France), the Fonds de Recherche en Santé Respiratoire (appel d’offres 2018 emis en commun avec la Fondation du Souffle, Paris, France), ADIR Association and the Foundation Charles Nicolle (Rouen, France). M.C.B.-F. is supported by the São Paulo Research Foundation (FAPESP 2015/17707-5 and 2018/06138-8). L.D.R. is supported by the BC Cancer Foundation and the University of British Columbia, Faculty of Dentistry. E.A.M. is supported by CIHR and the UBC, Faculty of Medicine and is a Vanier Canada Graduate scholar. G.D. is a senior scientist of the Beatrice Hunter Cancer Research Institute (BHCRI), and M.S.-W. is a trainee in the Cancer Research Training Program of the BHCRI, with funds provided by the QEII Health Sciences Centre Foundation and GIVETOLIVE. Publisher Copyright: © 2020, Springer Nature Switzerland AG.

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N2 - CD4+ T helper (TH) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, naïve TH cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector TH cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of TH cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators.

AB - CD4+ T helper (TH) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, naïve TH cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector TH cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of TH cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators.

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Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Abstract

Publication series

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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