Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Florian Guisier, Mateus Camargo Barros-Filho, Leigha D. Rock, Megan Strachan-Whaley, Erin A. Marshall, Graham Dellaire, Wan L. Lam

Résultat de recherche: Chapter

9 Citations (Scopus)

Résumé

CD4+ T helper (TH) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, naïve TH cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector TH cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of TH cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators.

Langue d'origineEnglish
Titre de la publication principaleAdvances in Experimental Medicine and Biology
Maison d'édition Springer
Pages35-51
Nombre de pages17
DOI
Statut de publicationPublished - 2020

Séries de publication

PrénomAdvances in Experimental Medicine and Biology
Volume1224
ISSN (imprimé)0065-2598
ISSN (électronique)2214-8019

Note bibliographique

Funding Information:
This work was supported by grants from the Canadian Institutes of Health Research (CIHR FDN-143345 to W.L.L. and PJT-156017 to G.D.) and scholarships from CIHR, Vanier Canada, and the BC Cancer Foundation. F.G. is supported by the Ligue nationale contre le cancer (Paris, France), the Fonds de Recherche en Santé Respiratoire (appel d’offres 2018 emis en commun avec la Fondation du Souffle, Paris, France), ADIR Association and the Foundation Charles Nicolle (Rouen, France). M.C.B.-F. is supported by the São Paulo Research Foundation (FAPESP 2015/17707-5 and 2018/06138-8). L.D.R. is supported by the BC Cancer Foundation and the University of British Columbia, Faculty of Dentistry. E.A.M. is supported by CIHR and the UBC, Faculty of Medicine and is a Vanier Canada Graduate scholar. G.D. is a senior scientist of the Beatrice Hunter Cancer Research Institute (BHCRI), and M.S.-W. is a trainee in the Cancer Research Training Program of the BHCRI, with funds provided by the QEII Health Sciences Centre Foundation and GIVETOLIVE.

Publisher Copyright:
© 2020, Springer Nature Switzerland AG.

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

PubMed: MeSH publication types

  • Journal Article
  • Review

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