Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Florian Guisier; Mateus Camargo Barros-Filho; Leigha D. Rock; Megan Strachan-Whaley; Erin A. Marshall; Graham Dellaire; Wan L. Lam

doi:10.1007/978-3-030-35723-8_3

Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Florian Guisier, Mateus Camargo Barros-Filho, Leigha D. Rock, Megan Strachan-Whaley, Erin A. Marshall, Graham Dellaire, Wan L. Lam

Producción científica: Capítulo en Libro/Reporte/Acta de conferencia › Capítulo

9 Citas (Scopus)

Resumen

CD4+ T helper (T_H) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, naïve T_H cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector T_H cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of T_H cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators.

Idioma original	English
Título de la publicación alojada	Advances in Experimental Medicine and Biology
Editorial	Springer
Páginas	35-51
Número de páginas	17
DOI	https://doi.org/10.1007/978-3-030-35723-8_3
Estado	Published - 2020

Serie de la publicación

Nombre	Advances in Experimental Medicine and Biology
Volumen	1224
ISSN (versión impresa)	0065-2598
ISSN (versión digital)	2214-8019

Nota bibliográfica

Funding Information:
This work was supported by grants from the Canadian Institutes of Health Research (CIHR FDN-143345 to W.L.L. and PJT-156017 to G.D.) and scholarships from CIHR, Vanier Canada, and the BC Cancer Foundation. F.G. is supported by the Ligue nationale contre le cancer (Paris, France), the Fonds de Recherche en Santé Respiratoire (appel d’offres 2018 emis en commun avec la Fondation du Souffle, Paris, France), ADIR Association and the Foundation Charles Nicolle (Rouen, France). M.C.B.-F. is supported by the São Paulo Research Foundation (FAPESP 2015/17707-5 and 2018/06138-8). L.D.R. is supported by the BC Cancer Foundation and the University of British Columbia, Faculty of Dentistry. E.A.M. is supported by CIHR and the UBC, Faculty of Medicine and is a Vanier Canada Graduate scholar. G.D. is a senior scientist of the Beatrice Hunter Cancer Research Institute (BHCRI), and M.S.-W. is a trainee in the Cancer Research Training Program of the BHCRI, with funds provided by the QEII Health Sciences Centre Foundation and GIVETOLIVE.

Publisher Copyright:
© 2020, Springer Nature Switzerland AG.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

PubMed: MeSH publication types

Journal Article
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10.1007/978-3-030-35723-8_3

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Guisier, F., Barros-Filho, M. C., Rock, L. D., Strachan-Whaley, M., Marshall, E. A., Dellaire, G., & Lam, W. L. (2020). Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment. En Advances in Experimental Medicine and Biology (pp. 35-51). (Advances in Experimental Medicine and Biology; Vol. 1224). Springer. https://doi.org/10.1007/978-3-030-35723-8_3

Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment. / Guisier, Florian; Barros-Filho, Mateus Camargo; Rock, Leigha D. et al.
Advances in Experimental Medicine and Biology. Springer, 2020. p. 35-51 (Advances in Experimental Medicine and Biology; Vol. 1224).

Producción científica: Capítulo en Libro/Reporte/Acta de conferencia › Capítulo

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Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Resumen

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Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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