Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

J. Sawynok; N. Kato; V. Havlicek; F. S. LaBella

doi:10.1007/BF00491482

Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

J. Sawynok, N. Kato, V. Havlicek, F. S. LaBella

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

High concentrations of K⁺ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 μM) does not significantly alter the K⁺-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.

Original language	English
Pages (from-to)	78-81
Number of pages	4
Journal	Naunyn-Schmiedeberg's Archives of Pharmacology
Volume	319
Issue number	1
DOIs	https://doi.org/10.1007/BF00491482
Publication status	Published - Mar 1982
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology

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AB - High concentrations of K+ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 μM) does not significantly alter the K+-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.

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Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

Abstract

ASJC Scopus Subject Areas

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