Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

J. Sawynok; N. Kato; V. Havlicek; F. S. LaBella

doi:10.1007/BF00491482

Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

J. Sawynok, N. Kato, V. Havlicek, F. S. LaBella

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

24 Citas (Scopus)

Resumen

High concentrations of K⁺ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 μM) does not significantly alter the K⁺-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.

Idioma original	English
Páginas (desde-hasta)	78-81
Número de páginas	4
Publicación	Naunyn-Schmiedeberg's Archives of Pharmacology
Volumen	319
N.º	1
DOI	https://doi.org/10.1007/BF00491482
Estado	Published - mar. 1982
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

Pharmacology

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abstract = "High concentrations of K+ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 μM) does not significantly alter the K+-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.",

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AU - Havlicek, V.

AU - LaBella, F. S.

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AB - High concentrations of K+ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 μM) does not significantly alter the K+-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.

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Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

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