Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

J. Sawynok; N. Kato; V. Havlicek; F. S. LaBella

doi:10.1007/BF00491482

Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

J. Sawynok, N. Kato, V. Havlicek, F. S. LaBella

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24 Citations (Scopus)

Résumé

High concentrations of K⁺ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 μM) does not significantly alter the K⁺-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.

Langue d'origine	English
Pages (de-à)	78-81
Nombre de pages	4
Journal	Naunyn-Schmiedeberg's Archives of Pharmacology
Volume	319
Numéro de publication	1
DOI	https://doi.org/10.1007/BF00491482
Statut de publication	Published - mars 1982
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Pharmacology

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10.1007/BF00491482

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AU - Havlicek, V.

AU - LaBella, F. S.

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AB - High concentrations of K+ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 μM) does not significantly alter the K+-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.

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Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

Résumé

ASJC Scopus Subject Areas

Accès au document

Autres fichiers et liens

Empreinte numérique

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