On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Mark E. Devries; L. Ran; David J. Kelvin

doi:10.1006/smim.1999.0165

On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Mark E. Devries, L. Ran, David J. Kelvin

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.

Original language	English
Pages (from-to)	95-104
Number of pages	10
Journal	Seminars in Immunology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1006/smim.1999.0165
Publication status	Published - Apr 1999
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grants from the Heart and Stroke Foundation of Canada, MOTS, the Medical Research Council of Canada, JDFI-MRC. M.E. DeVries is an NSERC scholar and D. J. Kelvin is an MRC scholar.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/smim.1999.0165

Cite this

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abstract = "Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.",

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AU - Ran, L.

AU - Kelvin, David J.

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On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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