On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Mark E. Devries; L. Ran; David J. Kelvin

doi:10.1006/smim.1999.0165

On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Mark E. Devries, L. Ran, David J. Kelvin

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81 Citas (Scopus)

Resumen

Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.

Idioma original	English
Páginas (desde-hasta)	95-104
Número de páginas	10
Publicación	Seminars in Immunology
Volumen	11
N.º	2
DOI	https://doi.org/10.1006/smim.1999.0165
Estado	Published - abr. 1999
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
This work was supported by grants from the Heart and Stroke Foundation of Canada, MOTS, the Medical Research Council of Canada, JDFI-MRC. M.E. DeVries is an NSERC scholar and D. J. Kelvin is an MRC scholar.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

ODS de las Naciones Unidas

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abstract = "Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.",

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On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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