On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Mark E. Devries; L. Ran; David J. Kelvin

doi:10.1006/smim.1999.0165

On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Mark E. Devries, L. Ran, David J. Kelvin

Résultat de recherche: Article › examen par les pairs

81 Citations (Scopus)

Résumé

Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.

Langue d'origine	English
Pages (de-à)	95-104
Nombre de pages	10
Journal	Seminars in Immunology
Volume	11
Numéro de publication	2
DOI	https://doi.org/10.1006/smim.1999.0165
Statut de publication	Published - avr. 1999
Publié à l'externe	Oui

Note bibliographique

Funding Information:
This work was supported by grants from the Heart and Stroke Foundation of Canada, MOTS, the Medical Research Council of Canada, JDFI-MRC. M.E. DeVries is an NSERC scholar and D. J. Kelvin is an MRC scholar.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1006/smim.1999.0165

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abstract = "Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.",

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note = "Funding Information: This work was supported by grants from the Heart and Stroke Foundation of Canada, MOTS, the Medical Research Council of Canada, JDFI-MRC. M.E. DeVries is an NSERC scholar and D. J. Kelvin is an MRC scholar.",

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AB - Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.

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On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

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