Proton-Activated Chloride Channel: Physiology and Disease

Fanglin Peng; Yi Wu; Xianping Dong; Peng Huang

doi:10.31083/j.fbl2801011

Proton-Activated Chloride Channel: Physiology and Disease

Fanglin Peng, Yi Wu, Xianping Dong, Peng Huang

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

Original language	English
Pages (from-to)	11
Number of pages	1
Journal	Frontiers in Bioscience - Landmark
Volume	28
Issue number	1
DOIs	https://doi.org/10.31083/j.fbl2801011
Publication status	Published - Jan 16 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s). Published by IMR Press.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

PubMed: MeSH publication types

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.31083/j.fbl2801011

Cite this

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AU - Wu, Yi

AU - Dong, Xianping

AU - Huang, Peng

PY - 2023/1/16

Y1 - 2023/1/16

N2 - The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

AB - The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

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Proton-Activated Chloride Channel: Physiology and Disease

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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