Proton-Activated Chloride Channel: Physiology and Disease

Fanglin Peng; Yi Wu; Xianping Dong; Peng Huang

doi:10.31083/j.fbl2801011

Proton-Activated Chloride Channel: Physiology and Disease

Fanglin Peng, Yi Wu, Xianping Dong, Peng Huang

Résultat de recherche: Review article › examen par les pairs

2 Citations (Scopus)

Résumé

The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

Langue d'origine	English
Pages (de-à)	11
Nombre de pages	1
Journal	Frontiers in Bioscience - Landmark
Volume	28
Numéro de publication	1
DOI	https://doi.org/10.31083/j.fbl2801011
Statut de publication	Published - janv. 16 2023

Note bibliographique

Publisher Copyright:
© 2023 The Author(s). Published by IMR Press.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

PubMed: MeSH publication types

Journal Article
Review

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.31083/j.fbl2801011

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AU - Wu, Yi

AU - Dong, Xianping

AU - Huang, Peng

PY - 2023/1/16

Y1 - 2023/1/16

N2 - The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

AB - The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

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JO - Frontiers in Bioscience - Landmark

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Proton-Activated Chloride Channel: Physiology and Disease

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

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