Proton-Activated Chloride Channel: Physiology and Disease

Fanglin Peng, Yi Wu, Xianping Dong, Peng Huang

Résultat de recherche: Review articleexamen par les pairs

2 Citations (Scopus)

Résumé

The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

Langue d'origineEnglish
Pages (de-à)11
Nombre de pages1
JournalFrontiers in Bioscience - Landmark
Volume28
Numéro de publication1
DOI
Statut de publicationPublished - janv. 16 2023

Note bibliographique

Publisher Copyright:
© 2023 The Author(s). Published by IMR Press.

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology

PubMed: MeSH publication types

  • Journal Article
  • Review

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